Перегляд за Автор "Motronenko, V. V."

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    Bioethics In The Context Of Socio-Economic, Socio-Political And Cultural Development Of Society
    (КПІ ім.Ігоря Сікорського, 2021) Gryb, I. O.; Mironenko, V. I.; Motronenko, V. V.
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    Possibilities of Plant Preparations Use for Collagen Structure and Metabolism Disturbances Correction: Modern State of Problem
    (Igor Sikorsky Kyiv Polytechnic Institute, 2023) Bondarenko, L. B.; Kalachinskaya, M. M.; Serhiichuk, N. M.; Motronenko, V. V.; Biloshytska, O. K.
    The review summarizes information on possibilities of plant preparations use for collagen structure and me-tabolism disturbances correction. Biologically active compounds of plant origin can both stimulate and inhi-bit the biosynthesis of various types collagens, accelerate or slower down their catabolism, regulate the activi-ty of enzymes involved in the collagen's metabolism. Most of the studied compounds realize their effects si-multaneously by several mechanisms. Among them, the most common are the direct influence of the sub-stance on the processes of collagen genes expression and indirect influence via TGF-beta1- pathway. In ad-dition, a fairly common are effects on collagen synthesis by changing organism's pools of free amino acids (as the starting compounds for this protein synthesis) and by regulation of hydroxylases (performing collagen post-translational modifications and crosslinking). Besides TGF-beta1 others cytokines can also be involved in the processes of collagen metabolism regulation by compounds of plant origin. In particular, this is cha-racteristic of triterpenes and phytoestrogens. Such a variety of methods for collagens metabolism regulation creates a wide range of possibilities for developing new preparations based on extracts or pure plant com-pounds able to correct connective tissue collagen structure and metabolic disorders with minimal adverse ef-fects. Fundamentally different possibilities for the influence of plant organisms on collagens are opened with the use of genetically modified plants. Recombinant collagens allow to obtain proteins with new programmed features, making it possible to synthesize proteins with predetermined properties for medical use.
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    Powder Fixed Combination With Antiseptic and Barrier Properties for Wound Management: Safety and Efficacy Aspects
    (Igor Sikorsky Kyiv Polytechnic Institute, 2020) Dissette, Valeria; Cassino, Roberto; Bondarenko, L. B.; Motronenko, V. V.
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    Prevention of Biological Threats in Wartime
    (Igor Sikorsky Kyiv Polytechnic Institute, 2025) Khudetskyy, I. Yu.; Galkin, O. Y.; Lutsenko, T. M.; Holembiovska, O. І.; Kalashnikova, L. Ye.; Besarab, O. B.; Motronenko, V. V.; Biloshytska, O. K.; Dronko, L. M.
    Study aid “Prevention of biological threats in wartime” provides information on the structure of biological threats in wartime conditions. An analysis of biological threats in the history of wars is provided. An interactive analysis of the features of biothreats and biosecurity in the conditions of modern wars was conducted. Traditional infections as a means of hybrid warfare. The issue of binary and multi-component biological weapons was considered. Focused attention on the socalled infections of war. Study aid “Prevention of biological threats in wartime” is intended for professional development of biosafety and biosecurity specialists.
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    Serological methods in modern biotechnologies and their bioanalytical standardization
    (КПІ ім. Ігоря Сікорського, 2019) Komar, A. G.; Motronenko, V. V.; Gorshunov, Y. V.
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    Specifics of Development and Testing of Biological Origin Products
    (Igor Sikorsky Kyiv Polytechnic Institute, 2025) Lutsenko, T. M.; Galkin, O. Y.; Holembiovska, O. І.; Khudetskyy, I. Yu.; Kalashnikova, L. Ye.; Besarab, O. B.; Motronenko, V. V.; Biloshytska, O. K.; Dronko, L. M.
    Study aid “Specifics of Development and Testing of Biological Origin Productsprovides information on basic concepts, types of biological drugs and the role of biotechnology in their production, stages of development of biological drugs, methods of quality control of biological products. In addition, the peculiarities of GMO products are also considered. Regulatory requirements for products of biological origin were also considered. The training manual “Specifics of Development and Testing of Biological Origin Products” is intended for improving the qualifications of specialists in biosafety and bioprotection.
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    The use of lawn grasses for purification of soil from toxic Cr(VI)
    (Igor Sikorsky Kyiv Polytechnic Institute, 2023) Matvieieva, N. A.; Motronenko, V. V.
    Background. Environmental pollution with toxic compounds poses a danger to nature and humans. Various technologies for soil purification from toxic metals are being developed. Objective. The work was aimed to study the possibility of lawn grass using for soil purification from Cr(VI). Methods. Plant seeds (Festuca rubra L. 45%, Festuca arundinacea Schreb. 25%, Lolium perenne L. 20%, Poa pratensis L. 10%) were sown in a container at 24 °C and grown for two months to obtain a lawn. K2CrO4 was added to the soil (400 g) (variants: 1.0 g, No. 1 and 2.5 g, No. 2) The following parameters were determined in two, five and ten days after Cr(VI) addition to the soil: the content of Cr(VI) in the roots, aerial part, and the soil; the coefficient of Cr(VI) content reduction; total content of aerobic heterotrophic microorganisms (CFU/g). Results. In 2 days after Cr(VI) adding the roots accumulated Cr(VI) in more significant amounts than the leaves (16.6 and 15 times in No. 1 and No. 2). In 5 days, an increase in Cr(VI) concentration in the plants was detected. Cr(VI) concentration in the soil decreased in 5 days by 45.8 and 13.57 times in variants No. 1 and No. 2, respectively. Inhibition of soil microorganisms growth was detected. CFU number in the control sample was 7.2×108, and in experimental variants No. 1 and No. 2 – 5×106 and 1×106, respectively. Conclusions. The addition of K2CrO4 inhibited the growth of soil microorganisms. Lawn grasses composition was successfully used for Cr(VI) extraction from the soil. A notable (13.8 and 9.3 times) reduction in Cr(VI) content in the soil was observed in two days. This reduction progressed greatly in five days as well (91.8 and 85.0 times). Cr(VI) was accumulated in the root system and the leaves of the plants. Thus, the selected grasses can be used in bioremediation technologies to purify contaminated soil.
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    Оцінка ризиків у технології препарату на основі рекомбінантного інтерлейкіну-7 людини та її перспективна валідація
    (КПІ ім. Ігоря Сікорського, 2017) Луценко, Тетяна Миколаївна; Горшунов, Юрій Володимирович; Мотроненко, Валентина Василівна; Галкін, Олександр Юрійович; Lutsenko, T. M.; Gorshunov, Yu. V.; Motronenko, V. V.; Galkin, O. Yu.; Луценко, Татьяна Николаевна; Горшунов, Юрий Владимирович; Мотроненко, Валентина Васильевна; Галкин, Александр Юрьевич