Innovative Biosystems and Bioengineering: international scientific e-journal

Постійне посилання на фонд

https://ela.kpi.ua/handle/123456789/2175

ISSN 2616-177X (Online) Періодичність: 4 рази на рік
Рік заснування: 2017
Тематика: оригінальні й оглядові статті та короткі повідомлення з проблем прикладної біології, біомедицини, біотехнології, біоінженерії, біофізики, біоінформатики та хімії живого. Журнал передбачає системний підхід для об’єднання наукової думки фахівців різної спеціалізації, які працюють із науково-технічними розробками в галузі «life sciences»
Офіційний сайт: http://ibb.kpi.ua/

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Зараз показуємо 1 - 20 з 155

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A New Algorithm to Analyze the Video Data of Cell Contractions in Microfluidic Platforms
(Igor Sikorsky Kyiv Polytechnic Institute, 2018) Nikolov, Nikolay; Visone, Roberta; Nesteruk, Igor; Rasponi, Marco; Redaelly, Alberto; Ніколов, Микола Олександрович; Візоне, Роберта; Нестерук, Ігор Георгійович; Распоні, Марко; Редаеллі, Альберто; Николов, Николай Александрович; Визоне, Роберта; Нестерук, Игорь Георгиевич; Распони, Марко; Редаелли, Альберто
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Analysis of Fractional-Order Model of COVID-19 Pandemics With a Nonlinear Incidence Rate
(Igor Sikorsky Kyiv Polytechnic Institute, 2020) Varghese, Vinod; Bhoyar, Sonal; Nisar, Kottakkaran Sooppy
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Anode biofilm formation with applied external voltage
(Igor Sikorsky Kyiv Polytechnic Institute, 2023) Koltysheva, D. S.; Shchurska, K. O.; Kuzminskyi, Ye. V.
Background. The formation of an exoelectrogenic biofilm in a microbial fuel cell (MFC) is an important stage, because it affects later on current generation by the system. The fermented residue after methanogenesis as an inoculum contains not only exoelectrogenic microorganisms, but also methanogens, which reduce the productivity of MFC. The use of current allows the formation of a biofilm enriched with exoelectrogenic microorganisms. Objective. The purpose of our study was to establish the parameters of MFC under periodic application of external voltage. Methods. A two-chamber H-type MFC with a salt bridge between the chambers was used for the study. The anolyte was stirred with a magnetic stirrer for 4 h a day and a 3V voltage was simultaneously applied to create selective conditions for exoelectrogenic biofilm growth. Results. The application of external voltage stimulated the increase in the current and voltage of the MFC. With the periodic application of an external voltage, the MFC current increased to 788 ± 40 mA for the MFC with a resistor and without load. After disconnection and discharge, the MFC current dropped to 189 ± 10 mA for the MFC without load and to 154 ± 8 mA for the MFC with a resistor, respectively. Under the conditions of MFC operation without applying external voltage, the current was 960 ± 50 mA for MFC with an open circuit and 672 ± 35 mA for MFC with a closed circuit when a resistor is connected. For all MFC, the current gradually decreased over time. MFC demonstrated capacitive behaviour: after accumulating charge for 4 h, a discharge from 622 ± 30 mV to 462 ± 23 mV was observed. Microscopy showed fouling of the anode. Since the fermented residue after methanogenesis is mixed consortium, the anodic biofilm was also mixed consortium enriched with different species of exoelectrogens. Conclusions. Periodic application of external voltage allowed to increase the current by 17% and double the voltage compared to MFC without external voltage supply. However, after disconnecting the external voltage source, the MFC gradually discharged, that is, the current and voltage decreased. The maximum value of the current of the MFC with an open circuit was 22% more than the MFC with a closed circuit.
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Antibacterial activity of 1-dodecylpyridinium tetrafluoroborate and its inclusion complex with sulfobutyl ether-B-cyclodextrin against mdr acinetobacter baumannii strains
(Igor Sikorsky Kyiv Polytechnic Institute, 2023) Rogalsky, S.; Hodyna, D.; Semenyuta, I.; Frasinyuk, M.; Tarasyuk, O.; Riabov, S.; Kobrina, L.; Tetko, I.; Metelytsia, L.
Background.The bacterial pathogen Acinetobacter baumanniiis one of the most dangerous multi-drug-resistant (MDR) microorganisms, which causes numerous bacterial infections. Nowadays, there is an urgent need for new broad-spectrum antibacterial agents with specific molecular mechanisms of action. Long-chain 1-alkylpyridinium salts are efficient cationic biocides which can inhibit enzymes involved in the biosynthesis of bacterial fatty acids.Incorporating these compounds into inclusion complexes with cyclic oligosaccharide B-cyclodextrin can reduce their relatively high acute toxicity.Objective. The aim of this research was to develop new anti-A.baumanniiagents based on hydrophobic 1-alkylpyridinium salt and its inclusion complex with sulfobutyl ether B-cyclodextrin (SBECD). Methods. Hydrophobiccationic biocide 1-dodecylpyridinium tetrafluoroborate (PyrC12-BF4) and its inclu-sion complex with SBECD have been synthesized. The structure of the SBECD/PyrC12-BF4complex was characterized by 1H Nuclear Magnetic Resonance spectroscopy, as well as UV spectroscopy. In vitroanti-bacterial activity of the synthesized compounds was estimated against MDR clinical isolates of A. baumanniiusing standard disc diffusion method. Acute toxicity studies were performed on Daphnia magnamodel hydro-biont.Molecular docking was performed using the crystal structure of the A.baumannii3-oxoacyl-[acyl-carrier-protein] reductase(FabG).
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Antimicrobial Activity of Fomitopsis Officinalis (Vill.) Bondartsev & Singer in Pure Culture
(Igor Sikorsky Kyiv Polytechnic Institute, 2021) Mykchaylova, O. B.; Poyedіnok, N. L.
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Antimicrobial and cytotoxic characteristics of antibiotic streptofungin
(Igor Sikorsky Kyiv Polytechnic Institute, 2023) Klochko, V. V.; Todosiichuk, T. S.; Kobzysta, O. P.; Bobyr, V. V.
Background. Streptomycetes were and remain a source of new antimicrobial compounds of various nature. A new wave of interest in such research is associated with the possibilities of applied genomics to reveal the hidden biosynthetic potential of streptomycetes, and therefore the discovery of new practically valuable antimicrobial products. The problem of antibiotic resistance of pathogens can be solved by creating compositions of active substances of different nature to overcome the protective mechanisms of pathogens. Objective. The purpose of the work was to establish and evaluate the antimicrobial and cytotoxic characteristics of the new antibiotic streptofungin, synthesized by Streptomyces albus 2435 (CMIM-S-668) and its mutant strains 2435/М, UN44, 4S, US101, AE6, 105, 80/5. Methods. To establish the characteristics of streptofungin, the antagonistic activity of selected S. albus producer strains was determined (by the radial streak method), the minimum inhibitory concentration of the antibiotic (by the serial dilution method), and cytotoxicity was determined by the MTT test with resazurin. Results. The activity of the antibiotic streptofungin against Candida fungi (C. albicans, C. utilis) is shown. Minimum inhibitory concentrations of streptofungin were determined for C. albicans ATCC 10231 (10 μg/ml), B. subtilis ATCC 6633 (200 μg/ml) and P. aeruginosa ATCC 9027 (500 μg/ml). According to the resazurin test, streptofungin does not show a cytotoxic effect in a wide range of concentrations from 2.5 to 500 μg/ml, and therefore can be considered potentially permissible for humans and animals in the studied concentrations. Conclusions. The antagonistic activity of mutant strains of S. albus culture is due to the action of a complex of antimicrobial products that have a different antimicrobial spectrum and mechanism of action. The obtained results give reasons to consider streptofungin as a promising pharmaceutical substance with antifungal action, as well as to consider the possibility of its combination with the bacteriolytic enzyme complex of the same culture for the development of an antimicrobial agent with a wide spectrum of action.
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Arterial Blood Oxygen Saturation and Its Dynamics Due to the Environmental Electromagnetic Conditions
(Igor Sikorsky Kyiv Polytechnic Institute, 2018) Mamilov, S. O.; Gorgo, Yu. P.; Yesman, S. S.; Vácziová, M.; Prigancová, A.; Pet'ko, B.
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Aspects of Lyophilization of Cardiac Bioimplant
(Igor Sikorsky Kyiv Polytechnic Institute, 2021) Shchotkina, N. V.
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Attenuation of Paraquat-Induced Nephrotoxicity and Dysfunction in Male Wistar Albino Rats
(Igor Sikorsky Kyiv Polytechnic Institute, 2020) Ujowundu, C. O.; Anaba, P. I.; Ulinasombu, N. B.; Ujowundu, F. N.; Igwe, K. O.; Ogbuagu, H. D.
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Automated Assessment of a Students Circulatory System Functional State Using Martine's Test
(Igor Sikorsky Kyiv Polytechnic Institute, 2018) Voinyk, B. A.; Borisova, G. V.; Umanets, V. S.; Boiko, G. L.; Pavlov, A. V.; Nastenko, Ie. A.
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Bioinformatic Analysis of the Genetic Mechanism of Biomineralization of Biogenic Magnetic Nanoparticles in Bacteria Capable of Tumor-Specific Accumulation
(Igor Sikorsky Kyiv Polytechnic Institute, 2022) Gorobets, S.V.; Gorobets, O.Yu.; Kovalova, S.О.
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Biological Evaluation of Medical Devices in the Form of Suppositories for Rectal and Vaginal Use
(Igor Sikorsky Kyiv Polytechnic Institute, 2021) Dmytrenko, О. V.; Arkhypova, М. А.; Starosyla, D. B.; Rybalko, S. L.; Gevorkyan, M.; Galkin, A. Yu.
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Biological Risks of Using Non-Thermal Non-Ionizing Electromagnetic Fields
(Igor Sikorsky Kyiv Polytechnic Institute, 2020) Nizhelska, O. I.; Marynchenko, L. V.; Piasetskyi, V. I.
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Biomedical Engineering Education: Ukrainian Trajectory Through the Prism of World Experience. Status and Perspectives
(Igor Sikorsky Kyiv Polytechnic Institute, 2021) Galkin, Alexander; Галкін, Олександр
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Characterization of Placental Mesenchymal Stem Cells Spheroids after Generation, Hypothermic and Subnormothermic Storage
(Igor Sikorsky Kyiv Polytechnic Institute, 2019) Prokopiuk, V. Yu.; Hloba, N. S.; Prokopiuk, O. S.; Schedrov, A. O.; Musatova, I. B.
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Current Safety Data of the Complex Herbal Medicine with Sedative and Cardioprotective Actions
(Igor Sikorsky Kyiv Polytechnic Institute, 2018) Gorchakova, N.; Heimuller, E.; Galkin, A.
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Development of a New Method for Obtaining the Bioplastics Based on Microbial Biopolymers and Lignin
(Igor Sikorsky Kyiv Polytechnic Institute, 2022) Yurchenko, A.V.; Golub, N.B.; Jinping, L.
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Early Experimental Results of Nerve Gap Bridging with Silicon Microwires
(Igor Sikorsky Kyiv Polytechnic Institute, 2019) Likhodiievskyi, V. V.
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Effect of herbal extracts upon enhancing the quality of low-fat cottage cheese
(Igor Sikorsky Kyiv Polytechnic Institute, 2023) Ryzhkova, T. M.; Odarchenko, A. M.; Silchenko, К. P.; Danylenko, S. G.; Verbytskyi, S. B.; Heida, I. M.; Kalashnikova, L. E.; Dmytrenko, A. M.
Background. Alkaloids, glycosides, saponins, mucus, tannins, volatile oils, phytoncides, and other chemical compounds found in plants possess medicinal properties and act as biogenic stimulants. These substances are formed in isolated tissues of animal and plant origin during their adapting to adverse environmental conditions, exhibiting biological activity. Biogenic stimulants include plant extracts utilized in pharmacology and dairy cattle breeding to enhance immunity, prevent animal infertility, increase productivity, and elevate the level of protein and fat components in milk. This suggests the potential application of plant biopreparations in the dairy industry, particularly in the technology of low-fat cottage cheese, to enhance its protein content. Objective. The present study aims to investigate the effect of biological preparations used in low-fat cottage cheese production on its quality and assess the feasibility of the said preparation. Methods. The quality parameters and biological value were evaluated for low-fat cottage milk cheese made from low-fat cow's milk prepared for curdling, as well as the lactating enzyme preparation "Fromaza" in the amount of 0.1 g for each batch of the product dissolved in plant extracts-based biopreparations "Biosvit" and "Megasvit". In samples of raw milk, the mass fraction of fat, protein, and solids and density were determined. Physicochemical and biochemical parameters, as well as the amino acid composition of protein in milk, were determined using standardized methods. Results. The study revealed that the use of "Biosvit" increased the mass fraction of total protein in the pilot cheese batch by 0.4%, while "Megasvit" led to a decrease in total protein content by 0.52%. Additionally, "Biosvit" and "Megasvit" reduced the mass fraction of non-casein protein in the pilot cheese batches by 0.25% and 1.82%, respectively, and increased the level of casein protein by 0.65% and 1.43%, respectively, compared to the control. The cheese yield from every 100 kg of processed raw milk increased by 2.8% and 4.5%, respectively, when using "Biosvit" and "Megasvit" preparations, compared to the control. Conclusions. The effectiveness of the biological preparation "Megasvit", used to dissolve the enzyme "Fromaza", in improving the quality and biological value of low-fat cottage cheese has been confirmed.
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Effect of Plants Morphological Parameters on Plant-Microbial Fuel Cell Efficiency
(Igor Sikorsky Kyiv Polytechnic Institute, 2022) Rusyn, I.B.; Fihurka, O.M.; Dyachok, V.V.
Background. Plant-microbial fuel cell (PMFC) is an innovative biotechnology for the environmentally safe bioelectricitygeneration. The widespread use of bioelectrical systems(biosystems)is hindered by their insuf-ficient efficiencydue to limiting knowings of the relationship between bioelectricity generationand features of their biotechnological components.

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