Identification of correlation between total organic carbon and conductivity values of water for injection line and establishing total organic carbon range for a specific conductivity value at a water for injection line / loop of a specific water system
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Дата
2025
Науковий керівник
Назва журналу
Номер ISSN
Назва тому
Видавець
КПІ ім. Ігоря Сікорського ; ТОВ «Українська водна спілка»
Анотація
The present study investigated the relationship between conductivity and total organic carbon (TOC) values in water for injection (WFI) systems at a pharmaceutical facility in Uttarakhand. Measurements were takenat the inlet and outlet of water for injection return loops across three separate blocks over a 90-day period from October 2024 to January 2025. The findings indicated that each block required a distinct total organic carbon range, as total organic carbonlevels, while generally correlated with conductivity, were also influenced by factors such as pipeline length, diameter, and number of user points. Importantly, total organic carbon values could exceed specifications even if conductivity was within acceptable limits, highlighting the critical need for block-specific total organic carbon monitoring. Moreover, the total organic carbon range w.r.t. conductivity values can be defined based on the trends observed at specific water systems and these are more accurately illustrating the actual total organic carbon results and also can be hypothecated based on the online conductivity results of a water system or water for injection distribution system used in pharmaceutical industries. The study concludes that defining total organic carbon ranges relative to conductivity trends enhances water quality monitoring for pharmaceutical processes and ensures accurate control over organic contamination
Опис
Ключові слова
pharmaceutical facility, total organic carbon, water for injection, water quality, фармацевтичне виробництво, загальний органічний карбон, вода для ін'єкцій, якість води
Бібліографічний опис
Identification of correlation between total organic carbon and conductivity values of water for injection line and establishing total organic carbon range for a specific conductivity value at a water for injection line / loop of a specific water system / Saurabh Shukla, Natarajan Iyer, Balasaheb Gaikwad // Вода і водоочисні технології. Науково-технічні вісті. – 2025. – № 2(42). – С. 50-64. – Бібліогр.: 28 назв.