Development of amlodipine and enalapril combined tablets based on quality by design and artificial neural network for confirming of qualitative composition

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dc.contributor.authorBehei, Nataliia
dc.contributor.authorTryhubchak, Oksana
dc.contributor.authorPryymak, Bogdan
dc.date.accessioned2023-06-21T13:30:59Z
dc.date.available2023-06-21T13:30:59Z
dc.date.issued2022-08
dc.description.abstractUsing approaches of Quality by design, namely dispersion analysis, random balance method, regression analysis and neural networks, the composition and technology tablets based on amlodipine besylate and enalapril maleate have been developed. Using dispersion analysis was determined the effect of 30 excipients on 10 pharmaco-technological parameters of tablets. With the help of the desirability function, the leaders of the excipients were selected from 6 functional groups. It was confirmed that the composition with the best pharmaco-technological parameters, determined by using statistical methods, coincides with the results studies the synthesized Feed-forward neural network. The quantities of preferable excipients at 3 levels were identified by the random balance method. The relationship between the studied factors and the quality of the tablets was described by regression equations. Based on the placement of equal output lines, the optimal composition of amlodipine tablets with enalapril was established.uk
dc.format.pagerangeP. 779-789uk
dc.identifier.citationBehei, N. Development of amlodipine and enalapril combined tablets based on quality by design and artificial neural network for confirming of qualitative composition / Behei N., Tryhubchak O., Pryymak B. // Pharmacia. – 2022. – 69(3). – P. 779-789.uk
dc.identifier.doihttps://doi.org/10.3897/pharmacia.69.e86876
dc.identifier.orcid0000-0001-7680-8565uk
dc.identifier.urihttps://ela.kpi.ua/handle/123456789/57423
dc.language.isoenuk
dc.publisherBulgarian Pharmaceutical Scientific Society and Pensoft Publishersuk
dc.publisher.placeBulgariauk
dc.relation.ispartofPharmacia, 69(3), 2022uk
dc.subjecttabletsuk
dc.subjectquality by designuk
dc.subjectartificial neural networkuk
dc.subjectqualitative compositionuk
dc.titleDevelopment of amlodipine and enalapril combined tablets based on quality by design and artificial neural network for confirming of qualitative compositionuk
dc.typeArticleuk

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