(Bulgarian Pharmaceutical Scientific Society and Pensoft Publishers, 2022-08) Behei, Nataliia; Tryhubchak, Oksana; Pryymak, Bogdan
Using approaches of Quality by design, namely dispersion analysis, random balance method, regression analysis and neural networks, the composition and technology tablets based on amlodipine besylate and enalapril maleate have been developed. Using
dispersion analysis was determined the effect of 30 excipients on 10 pharmaco-technological parameters of tablets. With the help of
the desirability function, the leaders of the excipients were selected from 6 functional groups. It was confirmed that the composition
with the best pharmaco-technological parameters, determined by using statistical methods, coincides with the results studies the
synthesized Feed-forward neural network. The quantities of preferable excipients at 3 levels were identified by the random balance
method. The relationship between the studied factors and the quality of the tablets was described by regression equations. Based on
the placement of equal output lines, the optimal composition of amlodipine tablets with enalapril was established.